[Summary text]
Randomised parallel group trial
26 COPD patients (mean age 67 years, 77% males, mean FEV1=36% predicted) after
inpatient treatment for acute exacerbation
Rehabilitation: Within 4-7 days after admission, inpatient pulmonary rehabilitation
with endurance exercise (5 walking sessions/day for 10 days), followed by six months of
supervised home-based endurance
exercise (3 walking sessions/day for 6 months). Completion rate of pulmonary rehabilitation
of 65.2% (15 out of 23 patients)
Usual care: Standard inpatient care without exercise and standard community care with
respirologist. Follow-up: 76 weeks
Lungfunction, HLQoL, gangtest(6MWT), Åndenød, genindlæggelser
Study design: Randomized controlled trial
Study grouping: Parallel group
Baseline Characteristics
Intervention 1
Intervention 2
Control
Overall
Included criteria: Patients admitted to chest dis-eases department, Alexandria Main University Hospital witha primary diagnosis of acute exacerbation of COPD.
Excluded criteria: Exclusion criteria:(1) Hypoxemic patients at rest or exercise.(2) Comorbidity that could limit exercise training like car-diovascular, musculoskeletal or neuromuscular diseases.(3) Patients who attended a pulmonary rehabilitation pro-gram in the preceding year.
Pretreatment: No significant differences were found between groupsin terms of age, BMI, airflow obstruction, or arterial bloodgases
Intervention Characteristics
Intervention 1
Intervention 2
Control
Quality of life, SD
Walk test, SD
Country: Egypt
Authors name: Rasha Daabis
Institution: Dept. of Chest Diseases, Faculty of Medicine, Alexandria University, Alexandria, Egypt
Email: rgdaabis@yahoo.dk, rgdaabis@gmail.com
Address: Department of Chest Diseases, Faculty of Medicine, Alexandria University, Alazarita, Alkhartoom Square, Egypt
Outcomes
Quality of life: SGRQ, St. georges respiratory QuestionnaireWalk test: 6-min test
Study design: Randomized controlled trial
Study grouping: Parallel group
Baseline Characteristics
Intervention 1
Intervention 2
Control
Overall
Included criteria: Consecutive patients who were admitted with anAECOPD and were discharged from the hospital whofulfilled the study criteria were included in the study.Unknown what the inclusion criteria were
Excluded criteria: Severely ill patients who were unable to walk, orpatients with unstable cardiovascular disease (unstableangina or recent acute myocardial infarction), hadcognitive impairment, disabling arthritis, and severeneurological disease were excluded from the study
Pretreatment: The mean FEV1% in the case and control group was53.3±18.4 and 46.7±14.8, respectively. The mMRCBreathlessness Scale in the two groups during theinitial assessment was found to be similar
Intervention Characteristics
Intervention 1
Intervention 2
Control
Quality of life, SD
Walk test, SD
Country: India
Setting: in the department of Pulmonary Medicine atGovernment Medical College Hospital, Chandigarh
Authors name: Deepak TH
Institution: Department of Pulmonary Medicine, Government Medical College and Hospital
Email: prmohapatra@hotmail.com
Address: Department of Pulmonary Medicine, All IndiaInstitute of Medical Sciences, Bhubaneswar-751 019 (Odisha), India.
RCT
N=97, Rehab=47, Kontrol=50
Rehabilitation: The patient started inpatient programme as soon as medically appropriate as determined by the attending medical team. Inpatient programme: Supervised walking and upper-lower limb strengthening exercise at least 30min/day until discharge,
followed by outpatient programme: supervised exercise for 8 weeks (1 h session, twice weekly) and patient education (coping with dyspnea, the importance of a regular daily home exercise programme, management of activities of daily living, drugs, vaccines, airway clearance techniques, nutritional advice, self-management and action plans for exacerbations, stress and panic management, relaxation techniques, mood disturbance,
adapting to a chronic illness and end-of-life care). Only 19 (40%) patients assigned to early rehabilitation satisfied the a priori definition of adherence (attendance at 75% of
rehabilitation sessions)
Follow-up: 12 weeks
Usual care: Standardized care in accordance with the ATS/ERS COPD guidelines and standardized advice on exercise andmaintaining daily activities, but not further specified.
Follow-up:12 weeks
BMI, air-flow obstruktion, åndenød, gangtest (6MWT), HRQoL, genindlæggelser, antal sengedage,
Follow-up: 3 måneder fra baseline
RCT
29 COPD patients (mean age 64 years, 90% males, mean FEV1=36% predicted) after
inpatient treatment for acute exacerbation
Rehabilitation: Within 6-8 days after admission, inpatient pulmonary rehabilitation
with endurance exercise (5 walking sessions/day for 10 days). Completion rate of pulmonary
rehabilitation not reported
Usual care: Standard inpatient care without exercise (not further specified). Follow-up:
11 days
Transition dyspnea index, 6MWD
31 randomised, 29 completed
RCT
N=60, rehab=30, ingen rehab=30
8 ugers rehab 2-3 gange om ugen, aerob gang og cykel træning
Adverse events, genindlæggerser, åndenød(mMRC) HRQoL(SGRQ), gangtest(6MWT), C-P exercise test (VO2 max)
6 months follow-up
Study design: Randomized controlled trial
Study grouping: Parallel group
Baseline Characteristics
Intervention 1
Intervention 2
Control
Overall
Included criteria: Patients who had been admitted with AECOPD to the Prince of Wales Hospital.
Excluded criteria: Exclusion criteria were: age 40 years; a diagnosis of asthma; chronic lung disaes other than COPD (eg, pneumoconiosis, pulmonary fibrosis); very vsevere medical illness that would affect the patient's ability to participate in this study (eg, terminal malignancy); and unable to give informed consent.
Pretreatment: There was no difference in the demographic characteristics between the groups.
Intervention Characteristics
Intervention 1
Intervention 2
Control
Mortality, n
Quality of life, SD
Readmission due to excerbation, n
Walk test, CI
Hospitalization, SD, end of treatment
Country: Kina
Comments: Trial registration: NCT 01108835
Authors name: Fanny W S KO
Institution: Devision of Respiratory Medicine, Department of Medicine and Therapeutics, The Chinese University of Hong Kong
Email: dschui@cuhk.edu.hk
Address: Dept. of Medicine and therapeutics, The chinese University of Hong Kong. Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, New terratories. Hong Kong
Outcomes
Walk test: 6-min, change, longest follow-upQuality of life: SGRQ, change, longest follow-upReadmission: adjusted relative risk of readmission for COPD 95% CI. End of treatmentHospitilazation: days. End of treatmentDeath: End of treatment
RCT
N=42, Rehab=21, Kontrol=21
Rehabilitation: Multidisciplinary outpatient pulmonary rehabilitation (within 10 days of discharge) with endurance and strength exercise and patient education for 12 weeks (2 sessions/week). Completion rate of pulmonary rehabilitation of 85.7% (18 out of
21patients)
Usual care: Standard community care with respirologist. Follow-up: 12 weeks
Gangtest(SWT), HRQoL, genindlæggelser, sengedage, mortalitet
Follow-up: 12 uger
RCT
N=31, Rehab= 16, Kontrol=15
Rehabilitation: Supervised home-based pulmonary rehabilitation with endurance and strength exercise for 6 weeks (2 supervised sessions/week and daily unsupervised sessions). Completion rate of pulmonary rehabilitation of 76.9% (10 out of 13 patients)
Usual care: Standard community care with respirologist. Follow-up: 26 weeks
Gangtest (SWT), åndenød, HRQoL, hospitalsindlæggelser, exacerbationer
Follow-up: 3 måneder
RCT
N=36, tidlig rehab=19, sen rehab=17
12 week programme, in or outpatient rehabilitation center, 24 sessions (range 18-36), including both endurance and strenght, and education
Exacerbationsrate over 18 måneder, HRQoL(CRQ), åndenød(mMRC)
Study design: Randomized controlled trial
Study grouping: Parallel group
Baseline Characteristics
Intervention 1
Intervention 2
Control
Overall
Included criteria: Inclusion criteria were confirmed diagnosisof COPD prior to current admission and an increase inself-reported breathlessness on exertion.
Excluded criteria: Exclusioncriteria were inability to provide informed consent; acute cardiac event; and the presence of musculoskeletal, neurological and psychiatric co-morbidities that would prevent the delivery of PR.
Pretreatment: Both groups were well matched for age,lung function and exercise capacity. Randomization was not equal across both arms withn n=24 in the early PR group and n=12 in theD-PEPR group.
Intervention Characteristics
Intervention 1
Intervention 2
Control
Mortality, n
Mortality, n (longest follow-up)
Quality of life, SD
Readmission due to excerbation, n
ADL, SD
Dropouts, n
Quality of life, SD (longest follow-up)
Readmission due to excerbation, RR (longest follow-up)
ADL, SD (longest follow-up)
Hospitalization, SD (longest follow-up)
Fall, n
Walk test, SD (longest follow-up)
Walk test, SD
Walk test, CI
RCT
N=60, Rehab=30, Kontrol=30
Rehabilitation:Within a week after hospital discharged, outpatient pulmonary rehabilitation twice-weekly exercise (limb strengthening and aerobic activities) and education sessions, during 8 weeks. Completion rate of pulmonary rehabilitation of 77% (23 out
of 30). Patients were provided with general information about COPD and offered outpatient appointments with general practitioner or respiratory team. Follow-up: 12 weeks
Usual care: Patients were provided with general information about COPD and offered outpatient appointments with general practitioner or respiratory team. Not referred
further. Follow-up: 12 weeks
Hospitalsindlæggelser med exacerbation, muskelstryke, gangtest(SWT), HRQoL
Follow-up: 3 efter indlæggelse
RCT
43 COPDpatients (mean age 62 years, 85%males, FEV1=39%predicted) after inpatient
treatment for acute exacerbation
Rehabilitation: Outpatient pulmonary rehabilitation with endurance and strength exercise
for 6 months (3 sessions/week in first 3 months, then 2/week). Completion rate
of pulmonary rehabilitation of 70.8% (17 out of 24 patients)
Usual care: Standard community care with respirologist (not further specified). Followup:
208 weeks
6MWD, mortality
Selection bias (biased allocation to interventions) due to inadequate generation of a randomised sequence
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
Patients were allocated randomly to groups. It is unknown how this was done
Randomisation was done by block randomisation technique.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
Described as randomised; additional information not
available from trial report
random number generator
A random number generator was used to assign patients in the intervention or control group
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Puhan, Milo A., et al. "Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease."
Cochrane Database Syst Rev 10.10 (2011).
Nothing mentioned
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Puhan, Milo A., et al. "Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease."
Cochrane Database Syst Rev 10.10 (2011).
Selection bias (biased allocation to interventions) due to inadequate concealment of allocations prior to assignment
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
Nothing mentioned
Nothing mentioned
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
Nothing stated
not stated
A computer programme (allocation by minimisation) was used to assist the randomization of subjects in equal opportunity in either group
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Puhan, Milo A., et al. "Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease."
Cochrane Database Syst Rev 10.10 (2011).
Judgement Comment: Sealed envelope technique
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Puhan, Milo A., et al. "Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease."
Cochrane Database Syst Rev 10.10 (2011).
Performance bias due to knowledge of the allocated interventions by participants and personnel during the study
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
Nothing mentioned
Nothing mentioned
Nothing mentioned
Nothing mentioned
Nothing mentioned
Nothing mentioned
Nothing mentioned
Nothing mentioned
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
Nothing stated
Nothing stated
Nothing stated
Information not available from trial report
Not blinded
Not blinded
Nothing stated
Not blinded
An open study for the patients and therapist, but the research assistant performing lung function, walking tests and questionnaire tests was neither involved in the delivery of patients care nore aware of the randomisation
Nothing mentioned
Nothing mentioned
Nothing mentioned
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Puhan, Milo A., et al. "Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease."
Cochrane Database Syst Rev 10.10 (2011).
See Puhan, Milo A., et al. "Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease."
Cochrane Database Syst Rev 10.10 (2011).
See Puhan, Milo A., et al. "Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease."
Cochrane Database Syst Rev 10.10 (2011).
See Puhan, Milo A., et al. "Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease."
Cochrane Database Syst Rev 10.10 (2011).
Nothing mentioned
Nothing mentioned
Nothing mentioned
Nothing mentioned
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Puhan, Milo A., et al. "Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease."
Cochrane Database Syst Rev 10.10 (2011).
See Puhan, Milo A., et al. "Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease."
Cochrane Database Syst Rev 10.10 (2011).
See Puhan, Milo A., et al. "Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease."
Cochrane Database Syst Rev 10.10 (2011).
See Puhan, Milo A., et al. "Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease."
Cochrane Database Syst Rev 10.10 (2011).
Detection bias due to knowledge of the allocated interventions by outcome assessors
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
Nothing mentioned
Nothing mentioned
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
not stated
blinded
Nothing mentioned
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Puhan, Milo A., et al. "Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease."
Cochrane Database Syst Rev 10.10 (2011).
Judgement Comment: Nothing mentioned
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Puhan, Milo A., et al. "Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease."
Cochrane Database Syst Rev 10.10 (2011).
Attrition bias due to amount, nature or handling of incomplete outcome data
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
45 patients were enrolled in the study. Only 15 per group was assesed. Nothing mentioned on dropouts.
There was 60 patients enrolled, yet only 28 participants were included in the analysis. There is nothing stated on dropouts.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
not detected
not detected
No other apparent sources of bias
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Puhan, Milo A., et al. "Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease."
Cochrane Database Syst Rev 10.10 (2011).
Judgement Comment: Dropouts have been accounted for
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.OHTAC vurdering
See Puhan, Milo A., et al. "Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease."
Cochrane Database Syst Rev 10.10 (2011).
Reporting bias due to selective outcome reporting
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
No other apparent source of bias
No other apparent source of bias
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
not detected
misleading presentation of data on readmissions
Matches the study protocol
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Puhan, Milo A., et al. "Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease."
Cochrane Database Syst Rev 10.10 (2011).
Quote: "Health-related quality of life measures were gathered, but on analy- sis, there were insufficient complete data sets to enable accurate analysis so this has not been reported."
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Puhan, Milo A., et al. "Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease."
Cochrane Database Syst Rev 10.10 (2011).
Bias due to problems not covered elsewhere in the table
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
No other apparent source of bias
The inclusion criterias are not stated.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
none detected
none detected
No other apparent sources of bias
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Puhan, Milo A., et al. "Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease."
Cochrane Database Syst Rev 10.10 (2011).
Quote: "As a result of the original sample number not being met in the allocated time and lower than antici- pated uptake and retention issues, the trial was termi- nated prematurely and was deemed a failed trial."
See Giacomini, M., D. DeJean, and D. Simeonov. "PULMONARY REHABILITATION FOR PATIENTS WITH CHRONIC PULMONARY DISEASE (COPD): AN EVIDENCE BASED ANALYSIS." Ont Health Technol Assess Ser 12 (2012): 1-47.
See Puhan, Milo A., et al. "Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease."
Cochrane Database Syst Rev 10.10 (2011).