Study design: Randomized controlled trial
Study grouping: Parallel group
Open Label: YES
Baseline Characteristics
exercise group (intervention)
-
Mean age in years (SD): 11,7 (2,3)
-
Male (female): 6(4)
-
BMI, mean (SD): 20.9 (6.1)
no exercise (control)
-
Mean age in years (SD): 11.4 (2.3)
-
Male (female): 9(8)
-
BMI, mean (SD): 18.7 (3.9)
Included criteria: The study selection criteria took into consideration the classification defined by the Global Initiative for Asthma, forced expiratory volume in 1 s (FEV1) below 80% of
the predicted value and absence of any exacerbation or change in medication in the preceding 30 days.
Excluded criteria: Patients with cardiovascular disease, lung disease or any musculoskeletal disorder that could hamper evaluation or the performance of physical activity
Intervention Characteristics
exercise group (intervention)
-
Description: 3 times a week. Electric treadmill. 5 min stretching, 10 min warm-up, 20/30 min training. 5 min cool-down.
-
Duration (weeks): 6
-
Length of follow up (weeks):
no exercise (control)
-
Description:
-
Duration (weeks):
-
Length of follow up (weeks):
Continuous:
- FEV1 (L)
- PAQLQ-Symptom score (higher=better)
- PAQLQ total score (higher=better)
Country: Brazil
Authors name: Andrade, 2014
Institution: Instituto de Medicina Integral
Email: ftliviabandrade@gmail.com
Ambrosino Leite, 92 ap.204, Grac¸as, 52011-230 Recife, PE, Brazil.
Study design: Randomized controlled trial
Study grouping: Parallel group
Baseline Characteristics
physical activity intervention
-
Mean age in years (SD): 10.35 (2.2)
-
Gender, N=male (%): 64.5
-
Mean duration of asthma in years (SD): 5.42 (3.3)
control: activity as usual
-
Mean age in years (SD): 10.45 (2.1)
-
Gender, N=male (%): 64.5
-
Mean duration of asthma in years (SD): 4.80 (2.7)
Included criteria: Not described
Excluded criteria: Not described
Intervention Characteristics
physical activity intervention
-
Description: Group E underwent a submaximal aerobic training designed as amoderately intensive basketball training program including both lowerand upper extremity activities. During the 8-week training program thesessions were performed 3 times a week (Monday, Wednesday andFriday) for one hour in each session. A typical session in the gymnasiumstarted with warm-up and callisthenics (15 min) followed by submaximalbasketball training (30 /35 min), cool-down and flexibility exercises(10 min). Except daily routines, specific exercise training was not encouragedin group C. A regular home respiratory exercise program consistingof relaxation and breathing exercises was advised to both groups.
-
Duration (weeks): 8
-
Follow up (weeks): 0
control: activity as usual
-
Description: Home respiratory exercise program
-
Duration (weeks): 8
-
Follow up (weeks): 0
Continuous:
- Mean quality of life score (higher=better)
- Daily dose Budesonide in microgram
- asthma control score
- symptom score
- FEV1, liter
- PEF, liter/min
- Daily dose Fluticasone in microgram
- FEV1%predicted
- FVC%
- FEV1/FVC
- PEF (%)
Dichotomous:
- Maximal FEV1% decline after mannitol challenge test
- Maximal FEV1 % decline after exercise challenge test, 6 min. run
- Maximal FEV1% decline after Metacholin challenge test
- Maximal FEV1 decline% after Cold Air Challenge Test
Adverse Events:
- serious adverse events
- No. of acute asthma attacks during physical activity
Country: Turkey
Authors name: Basaran, 2006
Institution: Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Cukurova Unirversity
Email: sbasaran@cu.edu.tr
Address: Sibel Basaran, Department ofPhysical Medicine and Rehabilitation, Faculty of Medicine,Cukurova University, TR-01330 Adana, Turkey.
Study design: Randomized controlled trial
Study grouping: Parallel group
Baseline Characteristics
physical activity intervention
-
Mean age in years (SD): 14 ± 0.6
-
Gender, N=male (%): 100
-
Mean duration of asthma in years (SD):
control: activity as usual
-
Mean age in years (SD): 13.9 ± 0.8
-
Gender, N=male (%): 100
-
Mean duration of asthma in years (SD):
Included criteria: Inclusion in the study required one month of acclimatization to altitude (1400 m), 6 weeks without anyacute episode of wheezing, one year without emergency departmentvisits or hospitalization for acute asthma, and a basalFEV1 >70% of predicted. The diagnosis of asthma was madeon the basis of the following criteria: (1) personal or familialhistory of allergy; (2) personal history of acute wheezing; (3)reversible airway obstruction documented by lung functiontesting, ie, improvement of 15%, at least in FEV1 and/or 30%in forced expiratory flow25-75 by inhaling a bronchodilatator;(4) positive specific immunoglobulin E to inhaled allergens bya multi-allergen allergosorbent test (Phadiatop, Pharmacia,Uppsala, Sweden) and/or a cutaneous hypersensitivity to oneor several allergens; and (5) no evidence of other lung disease.
Excluded criteria: Asthma exacerbations withoral corticosteroid use and hospitalization for any reason duringthe protocol were exclusion criteria.
Intervention Characteristics
physical activity intervention
-
Description: The design of the training sessions wasadapted from Gimenez et al.25 The target heart rate was individualizedand corresponded to the AT level. Every 4 minutes,the subject was asked to sprint for 1 minute against thebreaking load corresponding to his MAP. During all sessions,heart rate was continuously monitored with a cardiofrequencymeter (Sport Tester PE 3000, Polar Electro, Kemple, Finland).A training instructor and a pulmonologist supervisedeach session to ensure that the clinical condition was stableand the training procedures were followed.
-
Duration (weeks): The training group exercised 3 times weekly for 6weeks, with each session consisting of 45 min0utes of continuouscycling activity.
-
Follow up (weeks): 0
control: activity as usual
-
Description: All subjects underwent clinical examination, anthropometricmeasurements, ECG and spirometry before enteringin the study. They then familiarized themselves with the exercisetesting procedures. Each subject performed one incrementalexercise test and one FV test, with pre- andpostexercise pulmonary function testing. The same evaluationwas repeated when the 6 weeks of training were completed.Testing was done blindly regarding the training groups. Peakflow rates were monitored twice daily. All treatment was givenunder direct medical supervision.
-
Duration (weeks): The same evaluationwas repeated when the 6 weeks of training were completed.
-
Follow up (weeks): 0
Continuous:
- Mean quality of life score (higher=better)
- Daily dose Budesonide in microgram
- asthma control score
- symptom score
- FEV1, liter
- PEF, liter/min
- Daily dose Fluticasone in microgram
- FEV1%predicted
Dichotomous:
- Maximal FEV1% decline after mannitol challenge test
- Maximal FEV1 % decline after exercise challenge test, 6 min. run
- Maximal FEV1% decline after Metacholin challenge test
- Maximal FEV1 decline% after Cold Air Challenge Test
Adverse Events:
- serious adverse events
- No. of acute asthma attacks during physical activity
Sponsorship source: Not described
Country: France
Authors name: Counil, 2003
Institution: Service de Pédiatrie I, Service d’- Exploration Fonctionnelle Respiratoire, Hôpital Arnaud de Villeneuve, and UFR STAPS, Laboratoire Sport Performance Santé,
Email: fcounil@ chu-montpellier.fr.
Address: F-P Counil, MD, PhD,Service de Pédiatrie I, 371 Avenue duDoyen Gaston Giraud, 34295 Montpellier,Cedex 5, France.
See Carson, 2013 for Risk of Bias
Study design: Randomized controlled trial
Study grouping: Parallel group
Baseline Characteristics
physical activity intervention
-
Mean age in years (SD):
-
Gender, N=male (%): 60
-
Mean duration of asthma in years (SD):
control: activity as usual
-
Mean age in years (SD):
-
Gender, N=male (%): 66.7
-
Mean duration of asthma in years (SD):
Included criteria: Not described
Excluded criteria: Not descirbed
Intervention Characteristics
physical activity intervention
-
Description: Taught huffing, a cough-tecnique also known as the forced expiratory technique. Emphasis was placed on the correct use of the bronchodilator spray and its use before physical activity. An asthma school was arranged for all parents and those children who were older than 11 years. The children in the training group were divided according to age into two groups for the physical training. The training was led by a physiotherapist and a physical education instructor and was held once a week for one year except during school-holidays. The children used bronchodilators before training. The physical training began with 10 min of gradually intensified warming up followed by 10-15 min of 45 sec intense training alternated with 30 sec rest (circuit training). This was followed in turn by various games e.g. relay racing. The session ended with free swimming.
-
Duration (weeks): 12 weeks
-
Follow up (weeks): 0
control: activity as usual
-
Description:
-
Duration (weeks): 12 weeks
-
Follow up (weeks): 0
Continuous:
- Mean quality of life score (higher=better)
- Daily dose Budesonide in microgram
- asthma control score
- symptom score
- FEV1, liter
- PEF, liter/min
- Daily dose Fluticasone in microgram
- FEV1%predicted
- FEV1 rest
Dichotomous:
- Maximal FEV1% decline after mannitol challenge test
- Maximal FEV1 % decline after exercise challenge test, 6 min. run
- Maximal FEV1% decline after Metacholin challenge test
- Maximal FEV1 decline% after Cold Air Challenge Test
Adverse Events:
- serious adverse events
- No. of acute asthma attacks during physical activity
Country: Sweden
Authors name: Edenbrandt, 1990
Institution: Departmen of Clinical Physiology and the Department of Paediatrics
Address: Departmen of Clinical Physiology and the Department of Paediatrics.University HospitalS-221 85 Lund Sweden
Study design: Randomized controlled trial
Study grouping: Parallel group
Baseline Characteristics
physical activity intervention
-
Mean age in years (SD): 11 (2)
-
Gender, N=male (%): 57.2
-
Mean duration of asthma in years (SD): 6.4 (2.3)
control: activity as usual
-
Mean age in years (SD): 10 (2)
-
Gender, N=male (%): 64.7
-
Mean duration of asthma in years (SD): 5.9 (2.2)
Included criteria: (i) asthma diagnosis and graduation of severity according to the Global Initiative for Asthma (GINA) guidelines (15); (ii) under medical treatment for at least 6 months befare the study; and (iii) on a stable phase of the disease-that is, without any recent (15 d) disease exacerbation or change in medication usage.
Excluded criteria:
Intervention Characteristics
physical activity intervention
-
Description: Educational program. This program comprised two once-a-week classes, each lasting 2 h. The core activity was based on an educational videotape about the "ABCs of Asthma," with an interactive class to clarify doubts. The program also included lessons on disease pathophysiology, use of medication (relief and maintenance), and a written plan of action in case of worsening of symptoms.Training program. Physical training was performed twice a week for 90 min during 16 wk. The program was divided into four parts: (i) 15 min of warm-up and stretching exercises, (ii) 30 min of aerobic exercise on cycle and/or treadmill, (iii) 30 min ofupper- and lower-limb and abdomen endurance exercises, and (iv) 15 min of cooling down, stretching, and relaxation. Aerobic training was performed at the heart rate (HR) corresponding to two thirds of the difference between the anaerobic threshold (AnT) and the respiratory compensation point (RCP) as obtained in the incremental CPET (see below). This exercise intensity was selected to provide a sufficiently high metabolic/cardiovascular stress (i.e" above AnT) but still sustainable for a 30-min period. There was an initial (eight sessions) build-up period in which training intensity was gradually increased to allow the children to reach the proposed exercise intensity. Intensity was then increased by 5% when the child was able to continuously perform the proposed activity for two consecutive days. Respiratory discomfort (modified Borg (6) scale) and HR (by a HR monitor) were followed every I 0 min throughout the aerobic training phase. Upper- and lower-body endurance exercise was performed with free weights at 70% of a I0-maximal repetition test. Participants performed two types of exercise with the upper limbs and two with the lower limbs (three sets of 15 repetitions). In addition, three flexion abdominal exercise sets were also performed (15 repetitions each).
-
Duration (weeks): 16
-
Follow up (weeks): 0
control: activity as usual
-
Description: Educational program. This program comprised two once-a-week classes, each lasting 2 h. The core activity was based on an educational videotape about the "ABCs of Asthma," with an interactive class to clarify doubts. The program also included lessons on disease pathophysiology, use of medication (relief and maintenance), and a written plan of action in case of worsening of symptoms.
-
Duration (weeks): 16
-
Follow up (weeks): 0
Continuous:
- asthma control score
- symptom score
- FEV1, liter
- FEV1%predicted
- PEF, liter/min
- Daily dose Fluticasone in microgram
- Daily dose Budesonide in microgram
- Mean quality of life score (higher=better)
- PAQLQ
Dichotomous:
- Maximal FEV1 % decline after exercise challenge test, 6 min. run
- Maximal FEV1% decline after Metacholin challenge test
- Maximal FEV1% decline after mannitol challenge test
- Maximal FEV1 decline% after Cold Air Challenge Test
Adverse Events:
- No. of acute asthma attacks during physical activity
- serious adverse events
Sponsorship source: This study was supported by FAPESP grants 2002/08422-7 and Conselho Nacional de Pesquisa (CNPq), Brazil. J. A. Neder, M. A. Martins, and C. R. F. Carvalho are established investigators of the CNPq.
Country: Brazil
Authors name: Fanelli, 2007
Institution: School of Medicine, University of Sao Paulo
Email: cscarval@usp .br.
Address: Prof. Celso R. F. Carvalho, School of Medicine, University of Sao Paulo, Department of Clinical Medicine, Av. Dr. Amaldo 455, sala 1216, 01246-903, Sao Paulo, SP, Brazi
Continuous outcomes:
Tina Povlsen PAQLQ numbers a taken from figure 2.
See Carson, 2013 for Risk of Bias
Study design: Randomized controlled trial
Study grouping: Parallel group
Open Label: YES
Baseline Characteristics
intervention: 12 week in-door exercise program
-
mean age in years (SD): 11.55 (1.01)
-
BMI, mean (SD): 19.69 (3.2)
control: no exercise
-
mean age in years (SD): 11.51 (1.42)
-
BMI, mean (SD): 21.39 (4.78)
Included criteria:
Excluded criteria:
Intervention Characteristics
intervention: 12 week in-door exercise program
-
Description:
-
Duration:
-
Length of follow up (weeks ):
control: no exercise
-
Description:
-
Duration:
-
Length of follow up (weeks ):
Continuous:
- FEV1(L)
- PAQLQ-symptom score (higher=better)
- Total PAQLQ-score (higher=better)
Sponsorship source: none stated
Country: Spain
Comments: none
Authors name: Pedro Angel Latorre-Roman
Address: University of Jaen, Jaen, Spain
Study design: Randomized controlled trial
Study grouping: Parallel group
Baseline Characteristics
physical activity intervention
-
Mean age in years (SD): 10.5 (0.9)
-
Gender, N=male (%): 87.5
-
Mean duration of asthma in years (SD):
control: activity as usual
-
Mean age in years (SD): 9.9 (1.0)
-
Gender, N=male (%): 87.5
-
Mean duration of asthma in years (SD):
Included criteria: Asthma diagnosed ac- cording to the ATS criteria14 who had been admitted to hospital for treatment participated in the study.
Excluded criteria: Not described?
Intervention Characteristics
physical activity intervention
-
Description: Before commencing the training programmethe work rate and corresponding heart rate at125% of LT were assessed in each subjectusing the swimming ergometer. The heart ratewas continuously monitored by radiometryand the swimming speed was regularly noted atthis intensity in a series of 25 m “crawls”. Itwas therefore possible for subjects to controltheir swimming speed by being informed of thetime taken to swim every 25 m. The trainingintensity was thus set to 125% of LT for eachsubject individually. During the six week trainingperiod the training group swam in a heatedindoor pool (30°C) for two 15 minute periodson six days of the week. A 10 minute break wastaken between the two periods. Once a weekblood lactate concentrations and heart ratewere measured in each subject after the first 15minute period to ensure that the trainingintensity remained at 125% of the subject’s LT.The training intensity was increased wherenecessary
-
Duration (weeks): 6
-
Follow up (weeks): 0
control: activity as usual
-
Description:
-
Duration (weeks): 6 weeks
-
Follow up (weeks): 0
Continuous:
- asthma control score
- symptom score
- FEV1, liter
- FEV1%predicted
- PEF, liter/min
- Daily dose Fluticasone in microgram
- Daily dose Budesonide in microgram
- Mean quality of life score (higher=better)
Dichotomous:
- Maximal FEV1 % decline after exercise challenge test, 6 min. run
- Maximal FEV1% decline after Metacholin challenge test
- Maximal FEV1% decline after mannitol challenge test
- Maximal FEV1 decline% after Cold Air Challenge Test
Adverse Events:
- No. of acute asthma attacks during physical activity
- serious adverse events
Sponsorship source: This study was supported by the Pollution-related HealthDamage Compensation and Prevention Association of Japan.
Country: Japan
Authors name: Matsumoto, 1999
Institution: Division of Pediatrics, National Minami Fukuoka Chest Hospital
Address: Fukuoka University, 45-1-7 Nanakuma, Fukuoka 814-0180, Japan
Continuous outcomes:
Elisabeth Ginnerup-Nielsen Kpascal
See Carson, 2013 for Risk of Bias
Study design: Randomized controlled trial
Study grouping: Parallel group
Open Label:
Cluster RCT:
Baseline Characteristics
physical activity intervention
-
Mean age in years (SD): 12.9(3.4)
-
Gender, N=male (%): 11
-
Mean duration of asthma in years (SD): 4.4(2.2)
control: activity as usual
-
Mean age in years (SD): 12.5(3.5)
-
Gender, N=male (%): 9
-
Mean duration of asthma in years (SD): 4.9(1.8)
Included criteria:
Excluded criteria:
Intervention Characteristics
physical activity intervention
-
Description: The exercise group undertook submaximal aerobic exercisedesigned as a moderately intensive training programmeincluding both lower and upper extremity activities. Duringthe 12-week training programme, between February and May2005, the sessions were held twice a week, for 50 min persession. All sessions were carried out in an indoor gymnasium.Subjects were instructed to use b2-agonists before the trainingor, if necessary, during the session. A typical session startedwith a warm-up period (10 min) with arm and leg exercise.This was followed by submaximal training (30–35 min),including aerobic exercises, strength training, and somebalance and coordination exercises, and a cool-down period(7–10 min). In order to offer an enjoyable training session,various recreational games were played.
-
Duration (weeks): 12
-
Follow up (weeks): 0
control: activity as usual
-
Description: The control groupsubjects continued their usual daily routine.
-
Duration (weeks): 12
-
Follow up (weeks): 0
Continuous:
- asthma control score
- symptom score
- FEV1, liter
- FEV1%predicted
- PEF, liter/min
- Daily dose Fluticasone in microgram
- Daily dose Budesonide in microgram
- Mean quality of life score (higher=better)
- PD20,metacholin (Provocative Dose of metacholin causing a 20% fall in FEV1 (higher dose=better)
- PAQLQ
- FEV1%pred
Dichotomous:
- Maximal FEV1 % decline after exercise challenge test, 6 min. run
- Maximal FEV1% decline after Metacholin challenge test
- Maximal FEV1% decline after mannitol challenge test
- Maximal FEV1 decline% after Cold Air Challenge Test
Adverse Events:
- No. of acute asthma attacks during physical activity
- serious adverse events
Sponsorship source: A. Moreira holds a grant from theFinnish Centre for InternationalMobility (Helsinki, Finland) and afellowship from the EuropeanAcademy of Allergy and ClinicalImmunology.
Country: Portugal
Authors name: Moreira, 2008
Institution: Dept of Immunology and, Biostatistics and Medical Informatics. Faculty of Medicine
Email: andremoreira@med.up.pt
Address: A. MoreiraServic¸o e Laborato´rio de ImunologiaFaculdade de Medicina daUniversidade do PortoAl. Prof. Hernaˆni Monteiro4202 PortoPortugal
See Carson, 2013 for Risk of Bias
Study design: Randomized controlled trial
Study grouping: Parallel group
Baseline Characteristics
physical activity intervention
-
Mean age in years (SD): 9.8 (1.8)
-
Gender, N=male (%):
-
Mean duration of asthma in years (SD):
control: activity as usual
-
Mean age in years (SD): 9.8 (1.8)
-
Gender, N=male (%):
-
Mean duration of asthma in years (SD):
Included criteria: regularly participated inexercise and/or were part of a sports team were excludedfrom the study. The diagnosis of asthma was based on historyof recurrent cough and wheezing with prolonged expirationtime which demonstrated clinical reversibility with a shortacting beta-2 agonist bronchodilator therapy
Excluded criteria: Those children who stated that they regularly participated in exercise and/or were part of a sports team were excludedfrom the study. Immunocompromised patients, patients with a history of chronic inflammation/rheumatological disorder, and patients with autoimmunediseases were excluded.
Intervention Characteristics
physical activity intervention
-
Description: received the pharmacological treatment and was assignedto an exercise programme carried out by the Physiotherapyand Rehabilitation Department. Children exercisedtwice a week for an hour on a bicycle for eight weeks.The rate of exercise was determined according to the resting heart rate of the children. Their submaximal heart ratewas determined as 50% higher than their resting heart rate.Their target heart rate during exercise was determinedas 80% of the submaximal heart rate. The pedalling raterequired to reach the target heart rate was determinedusing a pulse oximeter during exercise. During the eightweek exercise programme, 15 minutes of warm-up exercisewas followed by 45 minutes of cycling at the target heartrate.
-
Duration (weeks): 8
-
Follow up (weeks): 0
control: activity as usual
-
Description: pharmacologicaltreatment for eight weeks.
-
Duration (weeks): 8
-
Follow up (weeks): 0
Continuous:
- asthma control score
- symptom score
- FEV1, liter
- FEV1%predicted
- PEF, liter/min
- Daily dose Fluticasone in microgram
- Daily dose Budesonide in microgram
- Mean quality of life score (higher=better)
- FVC % predicted
Dichotomous:
- Maximal FEV1 % decline after exercise challenge test, 6 min. run
- Maximal FEV1% decline after Metacholin challenge test
- Maximal FEV1% decline after mannitol challenge test
- Maximal FEV1 decline% after Cold Air Challenge Test
Adverse Events:
- No. of acute asthma attacks during physical activity
- serious adverse events
Country: Turkey
Authors name: Onur, 2011
Institution: Celal Bayar University, Faculty of Medicine, Department of Biochemistry,
Email: ece.onur@bayar.edu.tr
Study design: Randomized controlled trial
Study grouping: Parallel group
Baseline Characteristics
physical activity intervention
-
Mean age in years (SD): 10.5 (1.2)
-
Gender, N=male (%): 70
-
Mean duration of asthma in years (SD):
control: activity as usual
-
Mean age in years (SD): 10.7 (1.2)
-
Gender, N=male (%): 75
-
Mean duration of asthma in years (SD):
Included criteria: age between 8 and 13 years; clinically diagnosed asthma; either suffer- ing from EIB, by a fall of 10% of FEV1 after exercise (as known by a physician) and/or fear of exercise as observed by a general practitioner, a classroom teacher or by parents having observed exercise avoidance behaviour.
Excluded criteria:
Intervention Characteristics
physical activity intervention
-
Description: The physical exercise programme consisted of group exercises twice a week for one hour in a gymnasium24 and one 20-minute exercise session per week at home, within a three-month period.25 Premedication (usually inhaled ß2-agonist) was taken before training as prescribed by the child’s paediatrician. Occasional episodes of wheezing following exer- cise were relieved by inhalation of salbutamol. The lessons in the gymnasium started with 10 minutes warming-up, followed by 20 minutes of fitness training (a) and 15–20 minutes of differ- ent physical activities (b). Before or after the exercise, explanation and information was given to the children about asthma and exercise to improve coping behaviour with asthma (c).
-
Duration (weeks): 12
-
Follow up (weeks): 0
control: activity as usual
-
Description: did not receive any extra care (or treatment).
-
Duration (weeks): 12
-
Follow up (weeks): 0
Continuous:
- asthma control score
- symptom score
- FEV1, liter
- FEV1%predicted
- PEF, liter/min
- Daily dose Fluticasone in microgram
- Daily dose Budesonide in microgram
- Mean quality of life score (higher=better)
- EIB fall %
- FVC
- FEV1/FVC
Dichotomous:
- Maximal FEV1 % decline after exercise challenge test, 6 min. run
- Maximal FEV1% decline after Metacholin challenge test
- Maximal FEV1% decline after mannitol challenge test
- Maximal FEV1 decline% after Cold Air Challenge Test
Adverse Events:
- No. of acute asthma attacks during physical activity
- serious adverse events
Sponsorship source: We are grateful to MJM Kaashoek, PHC Klijn, J Meys, AI Scholte for their contribution to the study.
Country: Holland
Authors name: vanVeldhoven 2001
Institution: Department of Educational Sciences, Faculty of Social Sciences, Utrecht University
Email: N.vanveldhoven@fss.uu.nl
Address: NHMJ van Veldhoven, Utrecht University, Faculty of Social Sciences, Department of Edu- cational Sciences, Heidelberglaan 1, 3584 CS Utrecht, The Netherlands
See Carson, 2013 for Risk of Bias
Study design: Randomized controlled trial
Baseline Characteristics
physical activity intervention
-
Mean age in years (SD): 10.3
-
Gender, N=male (%): 77.8
-
Mean duration of asthma in years (SD):
control: activity as usual
-
Mean age in years (SD): 11.7
-
Gender, N=male (%): 77.8
-
Mean duration of asthma in years (SD):
Included criteria: (1): Clinical: family history of asthma and/or personal history of eczema, conjunctivitis or rhinitis caused by a known allergen.(2): Allergic: all the children showed a cutaneous hypersensitivity to one or several allergens.(3): immunological blood IgE levels were determined by the paper radioimmunoabsorbent test (PRIST): Any values above 150 UI/ml were considered abnormal.
Excluded criteria:
Intervention Characteristics
physical activity intervention
-
Description: Indoor swimming - pool. Aerobic training.
-
Duration (weeks): 12
-
Follow up (weeks): 0
control: activity as usual
-
Description:
-
Duration (weeks): 12
-
Follow up (weeks): 0
Continuous:
- asthma control score
- symptom score
- FEV1, liter
- FEV1%predicted
- PEF, liter/min
- Daily dose Fluticasone in microgram
- Daily dose Budesonide in microgram
- Mean quality of life score (higher=better)
- VO2 max
Dichotomous:
- Maximal FEV1 % decline after exercise challenge test, 6 min. run
- Maximal FEV1% decline after Metacholin challenge test
- Maximal FEV1% decline after mannitol challenge test
- Maximal FEV1 decline% after Cold Air Challenge Test
Adverse Events:
- No. of acute asthma attacks during physical activity
- serious adverse events
Country: France
Authors name: Varray,1995
Institution: Laboratoire, sport sante development, UFR STAPS
Address: Laboratoire, sport sante development, UFR STAPS700 Avenue du Pic Saint Loup, 34090 Montpellier. France
See Carson, 2013 for Risk of Bias