[Summary text]
Study design: Randomized controlled trial
Study grouping:
Open Label:
Cluster RCT:
Baseline Characteristics
FBT
Individual therapy
Included criteria: Participants, male or female, were eligible if they were aged12 to 19 years, which represented the potential full range forprecollege adolescents still living with their families or adultcaregivers, and met the operational definition of the DSM-IVcriteria for BN. Participants meeting the criteria for the “purgingsubtype” and the “nonpurging subtype” were included. Inaddition, participants who did not meet the DSM-IV bingeand-purge frequency criteria were included, provided theybinged or purged at least once per week for 6 months and metall other DSM-IV criteria for BN (ie, the combined frequencyof bulimic behaviors had to equal at least 24 episodes over thepast 6 months, averaging about 1 episode per week).
Excluded criteria: Participants were excluded if 1 of the following factors waspresent: associated physical or psychiatric disorder necessitatinghospitalization; insufficient knowledge of English that wouldprohibit understanding treatment; current physical dependenceon drugs or alcohol; current low body weight (body massindex [calculated as weight in kilograms divided by height inmeters squared] 17.5), thereby excluding patients with anexisting AN binge-and-purge subtype; current treatment for theeating disorder or current use of medication known to affecteating or weight; and physical conditions (eg, diabetes mellitusor pregnancy) or treatments known to influence eating orweight. Patients taking antidepressant medications were not excludedprovided they were taking a stable dose for 4 weeks.However, given the established antibulimic effects of fluoxetine,13 patients taking 50 mg or more were excluded.
Intervention Characteristics
FBT
Individual therapy
Continuous:
Dichotomous:
Sponsorship source: Financial Disclosure: Dr le Grange receives royalties fromGuilford Press.Funding/Support: This study was supported by grant K23MH001923 from the National Institute of Mental Health(Dr le Grange).
Country: USA
Setting: outpatient
Comments:
Authors name: Daniel le Grange
Institution: Departments of Psychiatry, The University of Chicago, Chicago, Illinois
Email: legrange@uchicago.edu
Address: Daniel le Grange, PhD, Department ofPsychiatry, The University of Chicago, 5841 S MarylandAve, MC3077, Chicago, IL 60637
Identification:
Participants:
Study design:
Baseline characteristics:
Intervention characteristics:
Pretreatment:
Continuous outcomes:
Dichotomous outcomes:
Adverse outcomes:
Study design: Randomized controlled trial
Study grouping:
Open Label:
Cluster RCT:
Baseline Characteristics
FBT
Individual therapy
Included criteria: Consecutively referred patients were invited to participate ifthey were 13–20 years of age, met DSM-IV criteria for bulimianervosa or eating disorder not otherwise specified, and had atleast one “close other” to accompany them for “family treatment.”
Excluded criteria: We excluded patients with a body mass index below the10th percentile for age and sex (5), patients whose knowledge ofEnglish was insufficient to understand the treatment, and patientswith learning disability, severe mental illness, or substancedependence. We did not exclude patients taking antidepressantsprovided they had been on a stable dose for at least 4 weeks.
Intervention Characteristics
FBT
Individual therapy
Continuous:
Dichotomous:
Sponsorship source: Dr. Treasurereceives a consultancy fee from the Capio Hospital to provide carerworkshops. All other authors report no competing interests.Supported by grant 1206/88 from the Health Foundation, U.K., toDrs. Schmidt, Eisler, Treasure, Beecham, and Rabe-Hesketh. The authorsthank Dr. Rudolf Uher for helpful comments on the manuscript.
Country: United Kingdom
Setting: outpatient
Comments:
Authors name: Ulrike Schmidt
Institution: Section of Eating Disorders, Clinical Trials Unit, Centre for the Economics of Mental Health, and the Section of Family Therapy, Institute of Psychiatry, London
Email: u.schmidt@iop.kcl.ac.uk
Address: Dr. Schmidt, Section of Eating Disorders (PO59), Instituteof Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
Identification:
Participants:
Study design:
Baseline characteristics:
Intervention characteristics:
Pretreatment:
Continuous outcomes:
Dichotomous outcomes:
Adverse outcomes:
Selection bias (biased allocation to interventions) due to inadequate generation of a randomised sequence
Selection bias (biased allocation to interventions) due to inadequate concealment of allocations prior to assignment
Performance bias due to knowledge of the allocated interventions by participants and personnel during the study
Detection bias due to knowledge of the allocated interventions by outcome assessors
Attrition bias due to amount, nature or handling of incomplete outcome data
Reporting bias due to selective outcome reporting
Bias due to problems not covered elsewhere in the table